Blar i forfatter "Rønning, Leif Reidar Brenk"
-
Combined Therapy With Dobutamine and Omecamtiv Mecarbil in Pigs With Ischemic Acute Heart Failure Is Attributed to the Effect of Dobutamine
Rødland, Lars; Rønning, Leif Reidar Brenk; Kildal, Anders Benjamin; Myrmel, Truls; How, Ole-Jakob (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-10-23)Inotropic support in ischemic acute heart failure (AHF) is controversial. We tested a therapeutic principle for AHF by combining a low dose of omecamtiv mecarbil (OM; 0.25 mg/kg bolus plus 0.25 mg/kg/h) with a low dose of dobutamine (Dobut; 1.25 µg/kg/min). In 10 pigs subjected to myocardial ischemia by left coronary microembolization, this cotreatment increased cardiac power (CP) from 0.48 ± 0.14 ... -
The β3 Adrenergic Receptor Antagonist L-748,337 Attenuates Dobutamine-Induced Cardiac Inefficiency While Preserving Inotropy in Anesthetized Pigs
Rødland, Lars; Rønning, Leif Reidar Brenk; Kildal, Anders Benjamin; How, Ole-Jakob (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-09-23)Excessive myocardial oxygen consumption (MVO<sub>2</sub>) is considered a limitation for catecholamines, termed oxygen cost of contractility. We hypothesize that increased MVO<sub>2</sub> induced by dobutamine is not directly related to contractility but linked to intermediary myocardial metabolism. Furthermore, we hypothesize that selective b<sub>3</sub> adrenergic receptor (b<sub>3</sub>AR) ...